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Potential Link Made Between Factor VII and Recurrent Fetal Loss

A collaborative study published by Connie Miller, PhD of the Centers for Disease Control and Prevention with other U.S.-based researchers, shows that women with elevated levels of factor VII (FVII) are potentially at risk for recurrent fetal loss. “Hemostatic abnormalities can be detected in a portion of the women who have recurrent fetal loss. We measured factor VII coagulant activity (FVII:C) in 65 women with three or more fetal losses (recurrent cases), 31 women with one second or third trimester loss (late loss cases) and 81 women with only live births (controls),” stated Dr. Miller and colleagues. Results indicated that women who had experienced recurrent fetal loss often manifested significantly higher levels of FVII.

This is the first report of a substantial elevation of FVII in a population with recurrent fetal loss. The study is entitled “Elevated factor VII as a risk factor for recurrent fetal loss - Relationship to factor VII gene polymorphisms,” and appears in the June 2005 issue of Thrombosis and Haemostasis.

Source: Lab Business Week, August 21, 2005


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