NHF funds a broad range of research. Funds raised under NHF's It's Time for a Cure campaign are used to provide Career Development Awards for projects that would yield scientific information contributing to a cure for bleeding disorders such as hemophilia and von Willebrand disease. Areas of investigation may include, but are not limited to, gene therapy. Studies may be carried out at the subcellular, cellular, animal, or patient level.

NHF has also fostered bleeding disorders research by awarding Judith Graham Pool Postdoctoral Research Fellowships to physicians and scientists embarking on research careers.

The National Hemophilia Foundation Clinical Fellowship Program, funded through the generous support of Baxter BioScience, is intended to increase the number of skilled clinicians committed to providing comprehensive care for individuals with bleeding and clotting disorders and to prepare candidates for academic careers. The program is designed for licensed physicians who are seeking hands-on training in bleeding and clotting disorders care and research. Training will take place in qualified hemophilia/thrombophilia treatment centers in the United States.

NHF’s Nursing Excellence, Social Work Excellence and Physical Therapy Excellence Fellowships provide support to practitioners to conduct research or clinical projects in the field of bleeding disorders.