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Mettine Bos, Ph.D.
Children’s Hospital of Philadelphia
Philadelphia, PA
Project Title: Regulatory Mechanisms in the Activation of Blood Coagulation Factors
V and VIII
Sponsor: Rodney Camire, Ph.D.
Ruijin Su, MD, Ph.D.
Puget Sound Blood Center
Seattle, WA
Project Title: Targeting Dendritic Cells to Induce Immune Tolerance to Factor VIII
Sponsor: Neil Josephson, MD
Jyoti Mathur, Ph.D.
Stanford University School of Medicine
Stanford, CA
Project Title: Proficient AAV Vectors for the Treatment of Hemophilia B
Sponsor: Mark A. Kay, MD, Ph.D.
Jun-Jiang Sun, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Hemophilic Arthropathy: Gene Delivery Vectors for Determining Mechanisms and Therapy
Sponsor: Paul E. Monahan, MD
David Buchner, Ph.D.
University of Michigan
Ann Arbor, MI
Project Title: Identification of Chemical Modifiers of Coagulation
Sponsor: David Ginsburg, MD
Michael Herbert, Ph.D.
Stanford University
Stanford, CA
Project Title: Proficient AAV Vectors for the Treatment of Hemophilia B
Sponsor: Mark A. Kay, MD, Ph.D.
Jill Marie Johnson, MD
University of Michigan
Ann Arbor, MI
Project Title: Mechanism for the Ectopic Expression of Galgt2 in Endothelial Cells
Sponsor: David Ginsburg, MD
Tao Li, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Purification and Characterization of Vitamin K Epoxide Reductase
Sponsor: Darrel W. Stafford, MD
Zhijian Wu, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Development of Self-Complimentary (SC) Adeno-Associated Virus Type 5 (AAV-5) Vectors for Gene Therapy of Hemophilia B
Sponsor: R. Jude Samulski, Ph.D.
Christine L. Kempton, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Platelet Mechanism Regulating Thrombin Generation
Sponsor: Harold Roberts, MD
Ting-Chang Hsu, Ph.D.
Puget Sound Blood Center
Seattle, WA
Project Title: Structure of Factor VIII’s C Domains and their Epitopes
Sponsor: Arthur R. Thompson, MD, Ph.D.
Julie Fradette, Ph.D.
University of Pittsburgh
Pittsburgh, PA
Project Title: Development of a Novel Genomic Transfer Approach for the Treatment of Hemophilia Based on Transduction of Adipose Tissue Using Replication-Defective HSV-1 Vectors
Sponsor: Joseph C. Glorioso, Ph.D.
Andrey Garunovich Sarafanov, Ph.D.
American Red Cross Holland Laboratory
Rockville, MD
Project Title: Identification of Complement-Type Repeats of LRP Responsible for Interaction with A2 Domain of Factor VIII
Sponsor: Evgueni Saenko, Ph.D.
Hongmin Sun, Ph.D.
University of Michigan Medical School
Ann Arbor, MI
Project Title: Function of Coagulation Factor V in Plasma and Platelet Pools
Sponsor: David Ginsburg, MD
Lisa S. Webb, Ph.D.
The Jackson Laboratory
Bar Harbor, ME
Project Title: Exploiting Mouse Models to Elucidate the Cellular and Molecular Mechanisms Involved in the Pathogenesis of Platelet Storage Pool Deficiencies
Sponsor: Luanne L. Peters, Ph.D.
Anja Ehrardt, Ph.D.
Stanford University
Stanford, CA
Project Title: Development of Improved Adenoviral Vectors Lacking All Adenoviral Coding Sequences for Hemophilia Gene Therapy
Sponsor: Mark A. Kay, MD, Ph.D.
Peter Vincent Jenkins, Ph.D.
University of Rochester Medical School
Rochester, NY
Project Title: Study of Interactive Sites of Factor VIIIa with Factor IXa
Sponsor: Philip J. Fay, Ph.D.
Bin Zhang, Ph.D.
University of Michigan Medical School
Ann Arbor, MI
Project Title: Molecular Mechanisms of Combined Factors V and VIII Deficiency
Sponsor: David Ginsburg, MD
Cathryn Sanghae Mah, Ph.D.
University of Florida
Gainesville, FL
Project Title: Treatment of a Mouse Model of Hemophilia Using AAV Vectors Expressing Murine Factor VIII
Sponsor: Barry J. Byrne, MD, Ph.D.
Lingfei Xu, MD, Ph.D.
Washington University School of Medicine
Saint Louis, MO
Project Title: Retroviral Vector-Mediated Gene Therapy for Canine Hemophilia B
Sponsor: Katherine Ponder, MD
Yubin Kang, MD
University of Iowa College of Medicine
Iowa City, IA
Project Title: Correction of Factor VIII Deficiency by Nonprimate Lentivirus-Based Gene Therapy
Sponsor: Paul B. McCray, Jr., MD
Frank Park, Ph.D.
Stanford University
Stanford, CA
Project Title: Mechanisms Involved in Transduction of Human Lentivirus in Liver: A Strategy for Hemophilia Gene Therapy
Sponsor: Mark A. Kay, MD, Ph.D.
Jo Chao Tsai, Ph.D.
Beth Israel Deaconess Medical Center / East
Boston, MA
Project Title: Vascular Bed-Specific Regulation of the VWF Gene
Sponsor: William C. Aird, MD
Bing-guan Chen, MD, Ph.D.
University of Michigan
Ann Arbor, MI
Project Title: Induction of Immune Tolerance to Factor IX
Sponsor: Kotoku Korachi, Ph.D.
You-Kyung Hwang, Ph.D.
Emory University
Atlanta, GA
Project Title: New Therapeutics for Hepatitis C
Sponsor: Curt H. Hagedorn, MD
Mark Thomas Reding, MD
University of Minnesota
Minneapolis, MN
Project Title: T Cell Epitopes on Factor VIII
Sponsors: Bianca M. Conti-Fine, MD and Nigel Key, MD
Paul Edward Monahan, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: AAV Hemophilia Gene Therapy Vectors
Sponsor: Richard Jude Samulski, Ph.D.
Jonathan Bernard Rosenberg, Ph.D.
The Blood Center of Southeastern Wisconsin
Milwaukee, WI
Project Title: Impact of VWF on Factor VIII Gene Targeting
Sponsor: Robert M. Montgomery, MD
Beth A. Bouchard, Ph.D.
New England Medical Center
Boston, MA
Project Title: Vitamin K-Dependent Carboxylase
Sponsor: Barbara C. Furie, Ph.D.
Steven Shahin Fakharzadeh, MD, Ph.D.
University of Pennsylvania
Philadelphia, PA
Project Title: Factor VIII Delivery via Skin
Sponsor: Haig H. Kazazian, Jr., MD
Dewey G. McCafferty, Ph.D.
Harvard Medical School
Boston, MA
Project Title: Vitamin K-Dependent Carboxylase
Sponsor: Christopher T. Walsh, Ph.D.
Degang Zhong, Ph.D.
Holland Laboratories
American Red Cross
Rockville, MD
Project Title: Interaction of Factor VIII with Factor IXa
Sponsor: Dorothea Scandella, Ph.D.
David Bruce Schowalter, MD, Ph.D.
University of Washington
Seattle, WA
Project Title: Persistent Expression of Factor IX
Sponsor: Mark A. Kay, MD, Ph.D.
Scott A. Tenenbaum, Ph.D.
Tulane University School of Medicine
New Orleans, LA
Project Title: HIV Resistance in Hemophiliacs
Sponsor: Cindy A. Leissinger, MD
Qicheng Yang, Ph.D.
The Salk Institute
San Diego, CA
Project Title: Gene Therapy for Hemophilia B
Sponsor: Inder M. Verma, Ph.D.
Dwight D. Koeberl, MD, Ph.D.
University of Washington
Seattle, WA
Project Title: Factor VIII Gene Therapy Vectors
Sponsor: A. Dusty Miller, Ph.D.
Sylvia T. Singer, MD
Children’s Hospital Oakland
Oakland, CA
Project Title: Factor VIII–Specific T Lymphocytes
Sponsors: Joseph E. Addiego, Jr., MD and Alexander H. Lucas, Ph.D.
Frederick K. Askari, MD, Ph.D.
University of Michigan Medical Center
Ann Arbor, MI
Project Title: Gene Therapy of Hemophilia B
Sponsor: James M. Wilson, MD, Ph.D.
William C. Nichols, Ph.D.
University of Michigan Medical Center
Ann Arbor, MI
Project Title: Genetics of Type I/III von Willebrand Disease
Sponsor: David Ginsburg, MD
Athan Kuliopulos, MD, Ph.D.
Harvard Medical School
Boston, MA
Project Title: Vitamin K-Dependent Carboxylase
Sponsor: Christopher T. Walsh, Ph.D.
Theo Palmer, Ph.D.
Fred Hutchinson Cancer Research Center
Seattle, WA
Project Title: Gene Therapy for Hemophilia A and B
Sponsor: A. Dusty Miller, Ph.D.
Jay Nelson Lozier, MD, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Replacement of the Factor IX Gene in a Canine Hemophilia B Model
Sponsor: Katherine A. High, MD
Josephine A. Carew, Ph.D.
Dana-Farber Cancer Institute
Boston, MA.
Project Title: Carbohydrate and Carbohydrate Sulfation in the Structure and Function of von Willebrand Factor
Sponsor: Dennis C. Lynch, MD, Ph.D.
Jack C. Rayner, DVM
The Blood Center of Southeastern Wisconsin
Milwaukee, WI
Project Title: Molecular and Cell Biology on von Willebrand Factor Variants
Sponsor: Robert R. Montgomery, MD
Monica D. Traystman, Ph.D.
Johns Hopkins University School of Medicine
Baltimore, MD
Project Title: Characterization of Gene Defects in Hemophilia A
Sponsor: Haig H. Kazazian, Jr., MD
James P. Evans, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: The Molecular Biology of Canine Hemophilia B
Sponsor: Harold Roberts, MD
Wadie Bahou, MD
University of Michigan
Ann Arbor, MI
Project Title: von Willebrand Disease: Molecular Studies in the Porcine Model
Sponsor: David Ginsburg, MD
Nancy Collins O’Brien, MD
University of Texas System Cancer Center
Houston, TX
Project Title (1987-1988): The Role of Hepatitis B and Hepatitis Delta Virus as Cofactors in the Acquired Immunodeficiency Syndrome in a Hemophilia Population
Project Title (1986-1987): The Role of Other Blood-Borne Infectious Agents as Cofactors in the Acquired Immunodeficiency Syndrome in a Hemophilia Population
Sponsor: W. Keith Hoots, MD
Paula Silverman, MD
University Hospitals of Cleveland
Cleveland, OH
Project Title (1987-1988): Studies in Fibrinolysis: Human Endothelial Cells in Culture and In Vivo Studies in Hemophilia
Project Title (1986-1987): Modulation of Plasminogen Activator and Plasminogen Activator from Human Endothelial Cells
Sponsor: George H. Goldsmith, MD
Michael Katzman, MD
Case Western Reserve University
Cleveland, OH.
Project Title: Mechanisms of Retroviral Integration Recombination
Sponsor: Jonathan P. Leis, Ph.D
Barbara G. Schach, MD
University of Washington
Seattle, WA
Project Title (1986-1987): DNA Analysis of the Factor IX Gene and the Role of B-Hydroxyaspartic Acid in the Vitamin K-Dependent Coagulation Factor
Sponsor: Earl W. Davie, MD
Project Title (1985-1986): DNA Analysis of the Factor IX Gene from a Patient with Hemophilia B
Sponsor: Kotoku Kurachi, Ph.D.
Bruce Harold Odegaard, Ph.D.
University of Vermont College of Medicine
Burlington, VT
Project Title: Characterization of Intermediates and Products of the Factor Xa-Catalyzed Activation of Factor V
Sponsor: Kenneth G. Mann, Ph.D.
Gordon Lewis Bray, MD
Children’s Orthopedic Hospital and Medical Center
Seattle, WA
Project Title: Functional Characterization of the Carboxy-Terminal Domain of Human
Factor IX
Sponsor: Arthur R. Thompson, MD, Ph.D.
Peggy Weintrub, MD
University of California at San Francisco
San Francisco, CA
Project Title: Immunologic Abnormalities in Patients with Hemophilia A
Sponsor: Arthur J. Ammann, MD
Carolyn Beach Daul, Ph.D., MD
Tulane University School of Medicine
New Orleans, LA
Project Title: Studies in Factor VIII: Effects of Commercial Preparations of Antihemophilic Factor in Immunocompetent Cell Populations
Sponsor: W. Abe Andes, MD
James B. Bussell, MD
Cornell University Medical College
New York, NY
Project Title: Immune Complexes and Immune Function in Hemophilia
Sponsor: Margaret W. Hilgartner, MD
Karen S. Kolba, MD
University of Arizona Health Sciences Center
Tucson, AZ
Project Title: A Pharmacologic Approach to the Treatment of Hemophilic Arthropathy
Sponsor: Eric P. Gall, MD
Michael W. Chopek, MD
University of Washington
Seattle, WA
Project Title: Studies on Factor VIII: Immunological and Biochemical Characterization of Procoagulant Activity and Subunit Interactions
Sponsor: Earl W. Davie, MD
Frederick A. Ernst, Ph.D.
Wright State University
Dayton, OH
Project Title: Biofeedback-Assisted Progressive Relaxation to Attenuate Complications of Hemophilia
Sponsor: Paul Kezdi, MD
David R. McCarroll, Ph.D.
University of Tennessee
Knoxville, TN
Project Title: Molecular Pathology of von Willebrand Disease
Sponsor: James P. Chen, Ph.D.
Jonathan C. Goldsmith, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Mutant Molecular Forms of Factor IX
Sponsor: Harold Roberts, MD
Gordon A. Vehar, Ph.D.
University of Washington
Seattle, WA
Project Title: Structure and Function of Factor VIII
Sponsor: Earl W. Davie, MD
Mary Ellen Switzer, MD
Duke University
Durham, NC
Project Title: Further Studies of the Molecular Structure-Function Relationships of the Human Antihemophilic / von Willebrand Proteins
Sponsor: Patrick A. McKee, MD
Annita Weidenbach, Ph.D.
Oklahoma Medical Research Foundation
Oklahoma City, OK
Project Title: Study of Cellular Interactions with Plasminogen Activator in Hemophilia and von Willebrand Disease
Sponsor: James H. Hampton, MD
Myatt S. Lipscomb, Jr., Ph.D.
Temple University
Philadelphia, PA
Project Title: Interaction Between Coagulation Factors and Platelets
Sponsor: P.N. Walsh, MD, Ph.D.
James E. Brown, Ph.D.
University of California
San Diego, CA
Project Title: Studies on Bovine Factor VIII and the Relationship to the Human Platelet Aggregating Factor (PAF)
Sponsor: Cecil Hougie, Ph.D.
John Lazarchick, MD
University of Connecticut Health Center
Farmington, CT
Project Title: Properties of Human Antibodies to Antihemophilic Factor
Sponsor: Leon W. Hoyer, MD
Eric Jaffee, MD
Cornell Medical School
New York, NY
Project Title: Synthesis of AHF Antigen by Cultured Endothelial Cells
Sponsor: Ralph L. Nachman, MD
Charles Heldebrant, Ph.D.
University of Washington
Seattle, WA
Project Title: Isolation and Characterization of Abnormal Factor VIII Present in von Willebrand Disease
Sponsor: Earl W. Davie, MD
Margaret E. Rick, MD
University of Connecticut
Farmington, CT
Project Title: Molecular Forms of Factor VIII
Sponsor: Leon W. Hoyer, MD
Judith C. Anderson, MD
Duke University School of Medicine
Durham, NC
Project Title: Biochemical Characterization of Human Factor VIII
Sponsor: Patrick McKee, MD
Andrew E. Weiss, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Project Title: Development of Immuno-Assay for Circulating Inhibitors to Factor VIII
Sponsor: Harold Roberts, MD
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