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Judith Graham Poole Postdoctoral Research Fellowship

2011 Janet and Jim Glass
JGP Postdoctoral Research Fellowship

Brian Ingram, PhD
The University of North Carolina at Chapel Hill

"Biochemical Characterization of Vitamin K Epoxide Reductase."

Dr. Ingram’s research project will study Vitamin K, and specifically the role of the Vitamin K Epoxide Reductase (VKOR) enzyme as it relates to coagulation. Deficiencies in VKOR, although rare, can lead to bleeding. Since the gene for VKOR was only recently identified in 2004, the goal of Dr. Ingram’s research will be to gain a better understanding of the enzyme’s biochemical properties and function. This information could lead to the design and development of more effective therapeutics for blood disorders.

Dr. Ingram earned his PhD in Biochemistry from Duke University and already has two first-author publications resulting from his PhD research. He has been a postdoctoral research fellow since 2010. He will pursue his research under the mentorship of Dr. Darrel Stafford, Professor of Biology and Pathology at UNC-Chapel Hill.

Funding for this award was made possible by Hemophilia of Georgia.

2011 Bill Riley, Jr.
JGP Postdoctoral Research Fellowship

Yingyu Chen, PhD
The Blood Research Institute, Milwaukee, Wisconsin

"In vivo Selection of Hematopoietic Stem Cells that are Genetically-Modified to Express Platelet-FVIII for Hemophilia A Gene Therapy."

The goal of Dr. Chen’s research is to examine a method for selectively expanding hematopoietic stem cells expressing the factor VIII transgene. She will also examine the immune consequences of this approach, based on the idea that gene transfer in platelets evades immune recognition. This research has the potential to elicit important clues to developing an approach for gene therapy of hemophilia A and hemophilia A with inhibitors.

Dr. Chen earned a PhD in hematology from Fujian Medical University in China. She already has more than 27 papers published in the Chinese medical literature. Her research in hemophilia and gene therapy will be under the mentorship of Dr. Qizhen Shi, MD, PhD, Associate Investigator at the Blood Research Institute and Assistant Professor of Pediatric Hematology at the Medical College of Wisconsin.

Funding for this award was made possible by Hemophilia of Georgia.

Click Here to Learn About the 2010 JGP Fellow and Previously Funded Recipients

Letter of Intent Deadline: February 7, 2014
Application Deadline: April 15, 2014
Award Start Date: July 1, 2014

NHF’s premier fellowship program is named in honor of Dr. Judith Graham Pool. Established in 1972, the Judith Graham Pool Postdoctoral Research Fellowship program has provided a long legacy of support for basic science and pre-clinical research in bleeding disorders. In 1965, Dr. Pool discovered a method of extracting clotting factor from human plasma to formulate cryoprecipitate. This breakthrough opened the door to a series of research developments that would revolutionize treatment for hemophilia and ultimately lead to its current management through recombinant replacement factor therapies.

Eligibility Requirements
Candidates for the Judith Graham Pool (JGP) Postdoctoral Research Fellowship must have completed doctoral training and apply for the JGP fellowship award from a doctoral, postdoctoral, internship or residency training program. Individuals with more than six postdoctoral years of experience or 6 years after completing their medical training are not encouraged to apply.  Established investigators or faculty members are also not eligible. Established investigators or faculty members are also not accepted. U.S. citizenship is not required, but applicants must be affiliated with a U.S. domestic-based organization (such as universities, colleges, hospitals, agencies and/or laboratories). Only non-commercial institutions and investigators associated with a non-commercial institution are eligible for NHF grant funding.

The JGP fellowship award recipient will be expected to spend at least 90% of their working time on the funded research project. The remaining 10% may be devoted to teaching or clinical work that is relevant to the research. The JGP recipient and his/her sponsor are expected to remain at their institution for the duration of the project. Letters of support by appropriate institutional officials will be required for application.

Scope of Research
Permissible research topics include pre-clinical or basic science research on the biochemical, genetic or hematologic aspects of hemophilia or von Willebrand disease. Other topics might focus on liver disease, HIV/AIDS, orthopedics, women’s health, or other therapeutic modalities as they pertain to bleeding disorders. All fellowship applications are subjected to a rigorous peer review process. Applications will be reviewed on scientific merit and scored in terms of significance, approach, innovation, investigator and environment.

All interested candidates need to submit a ‘Letter of Intent’ by no later than Friday, February 7, 2014. Letters will be evaluated by members of NHF’s Research Review Committee who will collectively decide upon those candidates invited to submit a JGP application. Upon receiving approval, selected candidates will have until Tuesday, April 15, 2014 to submit their complete JGP application to NHF.

LOI for NHF’s Judith Graham Pool Postdoctoral Fellowship Award should be sent to:

Angelina Wang
Director, Research & Medical Information
National Hemophilia Foundation
116 West 32nd Street, 11th Floor
New York, NY 10001-3212

JGP letters of intent need to be on institutional letterhead and will not be considered for review unless signed by the applicant. Letters should be no more than 2 pages and include a brief introduction of the candidate/researcher, their mentor, institution and a description of the proposed research project. Letters must also include a CV (or NIH-style biosketch) for both the candidate and his/her mentor. You may address the content of your letter to “Members of NHF’s Research Review Committee”.

For inquiries regarding this program, please contact Angelina Wang, either by email at or by phone at 800-424-2634, ext. 3727.