Dr. Kretz's research involves the development of a novel paradigm for screening protease specificity by coupling substrate phage display with high throughput sequencing. This project is a molecular examination using state-of-the-art genome sequencing technology to evaluate the interaction between ADAMTS13, VWF and other potential factors. The results of this project will make significant contributions to our understanding of ADAMTS13 biology, as well as provide insights into the diagnosis and pathogenesis of other coagulation disorders, such as TTP and VWD. Dr. Kretz received his Ph.D. in Biochemistry from McMaster University in Ontario, Canada. He has been a postdoctoral fellow in the lab of Dr. David Ginsberg since 2009. Funding for this award was made possible by the Colburn Keenan Foundation, the New York Hemophilia Chapter (NYHC), other NHF chapters as well as individual and corporate donors.