Janice Staber, MD, is currently an Assistant Professor and pediatric hematologist at the University of Iowa Children's Hospital. She is also a physician of the Iowa Hemophilia and Thrombosis Center in Iowa City. She received her undergraduate degree in biochemistry from the University of Iowa and her M.D. from the Carver College of Medicine at UI as well. Dr. Staber received strong mentorship under the guidance of Drs. Paul McCray and Steven Lentz during her post-doctoral research studies in gene therapy and hemophilia. She was subsequently appointed a faculty position at the University of Iowa Children's Hospital in 2010 and became an Assistant Professor of Pediatrics in the Division of Hematology/Oncology in 2013. Dr. Staber has been the recipient of an ASH award, a Bayer award, in addition to having been a Principal Investigator on several external and internal grants.
As the 2016 recipient of the NHF/Novo Nordisk Career Development Award, Dr. Staber will be studying the feasibility of a novel gene therapy strategy to cure hemophilia A. This work focuses on the application of nonviral vector developed from an insect-derived DNA transposon termed "piggyBac" to transduce hepatocytes in a murine model of hemophilia A. Dr. Staber will test the 'piggyBac' system with Factor VIII and von Willebrand factor to determine if the system will correct the bleeding problem and provide tolerance to inhibitors.