NBDF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.

James_Evans

The Molecular Biology of Canine Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Author(s):
James P. Evans

von Willebrand Disease: Molecular Studies in the Porcine Model

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
Wadie Bahou

The Role of Hepatitis B and Hepatitis Delta Virus as Cofactors in the Acquired Immunodeficiency Syndrome in a Hemophilia Population

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hepatitis/Liver Disease
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Nancy Collins O’Brien

Studies in Fibrinolysis: Human Endothelial Cells in Culture and In Vivo Studies in Hemophilia

Modulation of Plasminogen Activator and Plasminogen Activator from Human Endothelial Cells

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Plasminogen Activator 1 (PA1)
Author(s):
Paula Silverman

DNA Analysis of the Factor IX Gene and the Role of B-Hydroxyaspartic Acid in the Vitamin K-Dependent Coagulation Factor

DNA Analysis of the Factor IX Gene from a Patient with Hemophilia B

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Vitamin K
Hemophilia B (Factor IX/F9)
Author(s):
Barbara G. Schach
Michael_Katzman

Mechanisms of Retroviral Integration Recombination

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
HIV/AIDS
Author(s):
Michael Katzman

Per Dr. Katzman, the Judith Graham Pool Research Fellowship in Hemophilia from the National Hemophilia Foundation, that he received in 1986, was extremely formative. This initial support was the starting point that led to 25 years of productive research in HIV/AIDS, during which he believes he made significant contributions to understanding the mechanism of retrovirus integration (and the introduction of integrase inhibitors into clinical practice for treating HIV infection was particularly gratifying). The JGP Fellowship allowed him to transition during his Infectious Diseases Fellowship in a new direction. Having worked with Dr. Michael Lederman in the Department of Medicine at Case Western Reserve University and University Hospitals of Cleveland for two years on the immune dysfunction in HIV-infected hemophiliacs, this grant allowed him to enter the basic science laboratory of Jonathan Leis in the Department of Biochemistry, where he remained for 3 years in what — in essence — was a 5-year Fellowship in Infectious Diseases. Having gained this extra training, he was then prepared to obtain an independent faculty position and he moved to the Milton S. Hershey Medical Center and Penn State College of Medicine in the Departments of Medicine and Microbiology & Immunology in 1989. He continues in this faculty position, where he has combined basic research on retroviral integration with the clinical care of persons with HIV and other infectious Diseases, though he did close his basic science lab at the end of 2011. A description of his research and career record is available at: https://profiles.psu.edu/profiles/display/111718

Characterization of Intermediates and Products of the Factor Xa-Catalyzed Activation of Factor V

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Factor Xa
Author(s):
Bruce Harold Odegaard
Peggy_Weintrub

Immunologic Abnormalities in Patients with Hemophilia A

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Inhibitors
HIV/AIDS
Author(s):
Peggy Weintrub

Functional Characterization of the Carboxy-Terminal Domain of Human Factor IX

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Author(s):
Gordon Lewis Bray

Studies in Factor VIII: Effects of Commercial Preparations of Antihemophilic Factor in Immunocompetent Cell Populations

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Author(s):
Carolyn Beach Daul

Immune Complexes and Immune Function in Hemophilia

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Inhibitors
Author(s):
James B. Bussell

A Pharmacologic Approach to the Treatment of Hemophilic Arthropathy

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilic Arthropathy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Karen S. Kolba

Biofeedback-Assisted Progressive Relaxation to Attenuate Complications of Hemophilia

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Pain
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Frederick A. Ernst

Molecular Pathology of von Willebrand Disease

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Author(s):
David R. McCarroll

Studies on Factor VIII: Immunological and Biochemical Characterization of Procoagulant Activity and Subunit Interactions

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Author(s):
Michael W. Chopek

Structure and Function of Factor VIII

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Author(s):
Gordon A. Vehar

Mutant Molecular Forms of Factor IX

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Author(s):
Jonathan C. Goldsmith

Study of Cellular Interactions with Plasminogen Activator in Hemophilia and von Willebrand Disease

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Plasminogen Activator 1 (PA1)
Author(s):
Annita Weidenbach

Further Studies of the Molecular Structure-Function Relationships of the Human Antihemophilic/von Willebrand Proteins

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Von Willebrand Disease
Hemophilia A (Factor VIII/F8)
Author(s):
Mary Ellen Switzer

Interaction Between Coagulation Factors and Platelets

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Platelets
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Myatt S. Lipscomb, Jr.