In 1977, the FDA issued a guideline banning most women of "childbearing potential" from participating in clinical research studies. This was the result of certain drugs (most notably thalidomide) causing serious birth defects. At the time, the focus was on protecting the most vulnerable populations at all other costs.

The NHLI was renamed the National Heart, Lung, and Blood Institute (NHLBI), reflecting an expansion in blood-related activities within the Institute.

NHF successfully petitions Congress for The Hemophilia Treatment Centers Act of 1975, which authorizes federal funding to establish a network of comprehensive hemophilia treatment centers (Section 606 of P.L.94-63, amended Title XI of the Public Health Service Act) for the care and treatment of individuals with hemophilia. Hemophilia is a collection of genetic disorders that impair the body's ability to control bleeding. Common hemophilias are types A, B, and C. Von Willibrand disease is another genetic bleeding disorder included in these treatment centers. In 1976, approximately $3M are appropriated to fund more than 20 centers.

In 1976, the Children’s Hospital Los Angeles Hemophilia Treatment Center is established. It is one of the first Hemophilia Treatment Centers in the United States. The Center is originally called the Hemophilia Comprehensive Care Center.

NHF advocacy leads 24 states to create funding for hemophilia programs and treatment by 1976. Nationally, Senator Edward Kennedy sponsors legislation for public law S.66 in the 94th Congress.

George King was elected president of NHF.

For many patients, at-home care becomes a reality thanks to the industrial manufacturing and commercial availability of freeze-dried plasma concentrates of FVIII for HA and of the coagulation factors (II, VII, IX, X).

The Great Lakes Hemophilia Foundation becomes an NHF chapter. The chapter was founded in part by Dr. Jacob (Jay) Shanberge, the director of pathology and laboratory medicine at Mt. Sinai Hospital in Milwaukee.

NHF advocacy helps the state of Illinois dedicate $500,000 in public funding toward hemophilia assistance.

NHF advocates partner with Senator Harrison Williams of New Jersey to sponsor Senate Bill 1326, the Hemophilia Act of 1973, which ultimately passes in 1975. The bill eatabliahes $3M toward a hemophilia treatment center program nationwide.