Awarded/Presented
Tags
Bleeding Disorders Conference
Orthopedic and Physical Therapy
Researchers
Bethany Sloane, PT, DPT, Brittany Gurgel, PT, DPT, Nancy Durben, MSPT, PCS, Paul Sochacki, MS, David Oleson, PT, PCS, Michael Recht, MD, PhD

Background:

Activity limiting joint disease has greatly decreased with the introduction of prophylactic treatment for people with severe bleeding disorders. Previous research using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2TM), a standardized, normative, age and sex matched test of motor development, suggested motor development of males aged 4-21 years with bleeding disorders may be lower than age-matched peers.

Objective:

The primary purpose of this study was to compare the gross motor proficiency of boys with hemophilia ages 4-21 years followed at the Hemophilia Center at Oregon Health & Science University utilizing the BOT-2. Secondarily, we examined the relationship between joint health and gross motor proficiency.

Methods:

  1. a)  Participants and setting: Thirty-four subjects with either hemophilia A or B were recruited

    from our center. Data collection occurred during clinic visits or at the patients’ homes.

  2. b)  Design and Procedures: A prospective, cross-sectional study design was used. The Upper Limb Coordination, Bilateral Coordination, Balance, Running Speed and Agility, and Strength subtests of the BOT-2 were administered. Body composition, range of motion, presence of an inhibitor, and use of prophylaxis were collected at the time of testing or from chart review.

  3. c)  Analyses: Analysis of variance (ANOVA) modeling was used to compare BOT-2 scores of PWH with baseline BOT-2 scores estimated from the general population of comparable age.

Summary:

Mean Running Speed & Agility scores were greater among boys with hemophilia compared to the control population (p=0.0026). Agility scores were similar between boys with hemophilia A and B (p>0.60), and significantly greater compared to the control group (p=0.0153). No other significant differences were found comparing boys with hemophilia to the control group. Within the boys with hemophilia cohort, age-adjusted ANOVA found no significant differences in BOT-2 scores between subjects of different severities, treatment regimen (prophylaxis or episodic), or diagnoses (Hemophilia A or B).

Conclusion:

Boys with hemophilia have the same or better gross motor proficiency as age matched peers.