NHF funds a broad range of research programs that seek to increase our understanding of the science behind bleeding disorders, how they affect people's lives, and pathways to better treatments and cures.

Qizen Shi

Immune Response in Platelet-Derived FVIII Gene Therapy of Murine Hemophilia A

Year:
-
Grants:
Career Development Award
Gene Therapy
Hemophilia A (Factor VIII/F8)
Platelets
Author(s):
Qizhen Shi

Recombinant Factor VIIa and RL Platelets as a Hemophilia Therapy

Year:
-
Grants:
Career Development Award
Platelets
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Factor VII/F7
Author(s):
Alisa Wolberg

Pharmacogenomics of Hemophilia Therapy: Genetics of Inhibitor Antibody Response

Year:
-
Grants:
Career Development Award
Inhibitors
Author(s):
Jay Lozier
Studies of VWF Function in VWF-Platelet and VWF-FVIII Interactions

Studies of VWF Function in VWF-Platelet and VWF-FVIII Interactions

Year:
-
Grants:
Career Development Award
Von Willebrand Disease
Author(s):
Veronica Flood

Dr. Flood earned her undergraduate degree from Harvard University in 1995 and her doctorate from Tufts University in 1999. She is board certified in pediatrics as well as pediatric hematology/oncology. She has been serving as an Assistant Professor at the Medical College of Wisconsin, where she has been performing research and seeing patients since 2006.

As part of her NHF Career Development Award, Dr. Flood will study the common variants and interactions of the von Willebrand factor molecule as a means to enhance overall understanding and eventually improve upon current methods of von Willebrand disease testing. Using mouse models, she will investigate diagnostic alternatives by examining the interaction between ristocetin and its ability to bind to von Willebrand factor. As Dr. Flood states in her summary, "Improved testing for VWD will prevent patients with normal VWF function from receiving unnecessary treatment, while allowing more accurate assessment of patients with true defects in VWD."

Regulatory Mechanisms in the Activation of Blood Coagulation Factors V and VIII

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Factor V
Hemophilia A (Factor VIII/F8)
Author(s):
Mettine Bos
Use of Emergency Medical Identification in the Pediatric Hemophilia Population: A National Study

Use of Emergency Medical Identification in the Pediatric Hemophilia Population: A National Study

Year:
-
Grants:
Nursing Excellence Fellowship
Author(s):
Jocelyn Bessette Gorlin
Nurses and health care providers recommend Emergency Medical Identification (EMI) such as Medic Alert for children of all ages with hemophilia and other bleeding disorders, but most are unsure of what type should be used and where they should be located. This is because there are no guidelines on how EMI should be worn. This project will develop guidelines for the use of Emergency Medical Identification (EMI) and develop educational information for families of children with hemophilia. Guidelines will show recommended ages to wear EMI, its use with infants, and where it should be worn or if it should be carried. In addition, this project will review barriers for not wearing EMI based on our research, including perceived lack of need, sizing concerns for infants, and the fear of being different as expressed by adolescents.
Women with Severe and Moderate Hemophilia A and B and Other Bleeding Disorders: A Grounded Theory Study

Women with Severe and Moderate Hemophilia A and B and Other Bleeding Disorders: A Grounded Theory Study

Year:
-
Grants:
Social Work Excellence Fellowship
Author(s):
Jacqueline Lefkowitz
This study will collect data from interviews with women who have moderate or severe hemophilia or another congenital bleeding disorder. Participants will be asked to express the impact that a congenital bleeding disorder has on the development and maintenance of identity and social relationships. It will provide women a chance to share how they feel about the impact that living with a bleeding disorder has on their lives. The results of this study will be of benefit to treatment providers and the entire community as we come to better understand the unique experiences of this segment of the bleeding disorders population.

Proficient AAV Vectors for the Treatment of Hemophilia B (2007)

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia B (Factor IX/F9)
Gene Therapy
Author(s):
Jyoti Mathur

Self-Regulating HIV Vectors for Hemophilia A Gene Therapy

Year:
-
Grants:
Career Development Award
Gene Therapy
HIV/AIDS
Hemophilia A (Factor VIII/F8)
Author(s):
Yashuhiro Ikeda
Junjiang_Sun

Hemophilic Arthropathy: Gene Delivery Vectors for Determining Mechanisms and Therapy

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilic Arthropathy
Pain
Author(s):
Jun-Jiang Sun

Targeting Dendritic Cells to Induce Immune Tolerance to Factor VIII

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Inhibitors
Author(s):
Ruijin Su
Development of an Institution-Wide, Customizable, Computer-Based, Training Module

Development of an Institution-Wide, Customizable, Computer-Based, Training Module

Year:
-
Grants:
Nursing Excellence Fellowship
Author(s):
Robin Chapman
The purpose of this project is to request support for the development of a computer-based training (CBT) module designed to teach the care and treatment of patients with bleeding disorders to nursing staff in a large, multi-campus pediatric healthcare institution. The module will be designed to exist within an intranet environment accessed by all members of the healthcare institution. Core modules will include a description of each common bleeding disorder, a basic review of processes surrounding the multidisciplinary care of bleeding disorder patients, the involvement of other hospital departments in managing a patient with a bleeding treatment plan (e.g., blood bank, coagulation lab, hemophilia treatment center staff) and medications/factor products routinely used to treat them. The result, a custom-made bleeding disorder CBT, would be available at any time to any staff member on any of the institution's campuses being assigned to care for bleeding disorder patients, thus facilitating nursing education and patient care.
The Prevalence and Risk Factors for Depression in Adults with Hemophilia

The Prevalence and Risk Factors for Depression in Adults with Hemophilia

Year:
-
Grants:
Social Work Excellence Fellowship
Author(s):
Laurel Pennick, Maria Iannone
Despite the fact that adults with hemophilia fit the profile of a population at high risk for experiencing depression, not to mention the significant impact of depression on their overall well-being, there are almost no studies in the literature to document the incidence of depression for these patients. This study is designed to document the prevalence of depression in adults with hemophilia at our treatment center and to evaluate risk factors for depression in these patients as well as patients from Region VIII who have completed the Centers for Disease Control and Prevention's Quality of Life questionnaire. Evaluation of the information collected is expected to show that a significant percentage of adults with hemophilia are experiencing symptoms of depression. The Arizona Hemophilia and Thrombosis Center plans to use this information to apply for future funding to support the development of a depression care management plan, which will be incorporated into standard care.

Platelets as Modifiers of Phenotype in Hemophilia A

Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Platelets
Author(s):
Donald L. Yee

A Disease-Specific DNA Chip for von Willebrand Disease

Year:
-
Grants:
Career Development Award
Von Willebrand Disease
Author(s):
Bradley E. Aouizerat

Regulation of Factor V and VIII Secretion by an ER to Golgi Transport Receptor

Year:
-
Grants:
Career Development Award
Factor V
Hemophilia A (Factor VIII/F8)
Author(s):
Bin Zhang

Transposon Mediated Gene Therapy of Hemophilia

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Gene Therapy
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Li Liu

Individualized Phenotypic Prophylaxis for Hemophilia

Year:
-
Grants:
Career Development Award
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
Kathleen Brummel-Ziedins

Depletion of Immune Response to AAV-F.IX

Year:
-
Grants:
Career Development Award
Hemophilia B (Factor IX/F9)
Gene Therapy
Author(s):
Huang-Ge Zhang

Identification of Chemical Modifiers of Coagulation

Year:
-
Grants:
Judith Graham Pool Postdoctoral Research Fellowship
Hemophilia A (Factor VIII/F8)
Hemophilia B (Factor IX/F9)
Author(s):
David Buchner